Analytical Data
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基因名
SUMO4
- Application
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别名
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6EEV6
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表达区间
1-95aa
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分子量
37.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SUMO4 (Small Ubiquitin-like Modifier 4) is a member of the SUMO (Small Ubiquitin-like Modifier) family of proteins, which play a crucial role in post-translational modifications, particularly in the process of sumoylation. This modification involves the attachment of SUMO proteins to target proteins, influencing their stability, localization, and interactions. Although SUMO4 is structurally similar to its paralogs SUMO1, SUMO2, and SUMO3, its biological functions remain less understood, largely due to limited research. However, recent studies have suggested that SUMO4 is involved in various cellular processes, including stress response, inflammation, and immune regulation. Its association with autoimmune diseases and certain cancers has sparked interest in the exploration of SUMO4 as a potential biomarker and therapeutic target. Furthermore, the unique expression patterns of SUMO4 in different tissues, particularly in immune cells, highlight its significance in immune system function and disease pathology. Investigating the biochemical properties, interacting partners, and regulatory mechanisms of SUMO4 can provide valuable insights into its role in health and disease, potentially leading to novel therapeutic strategies aimed at modulating sumoylation pathways for various clinical applications. Researchers are increasingly employing recombinant SUMO4 proteins in biochemical assays to delineate their functional roles and to better understand how aberrations in SUMO4 signaling contribute to disease etiology. The study of SUMO4 thus represents a promising frontier in the field of molecular and cellular biology, with implications for understanding complex biological systems and developing targeted therapies.
