Analytical Data
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基因名
NOG
- Application
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别名
；
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13253
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表达区间
28-232aa
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氨基酸序列
QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
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分子量
23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOG, or noggin, is a secreted protein that plays a critical role in the regulation of bone and cartilage development by antagonizing bone morphogenetic proteins (BMPs). Its study has gained prominence due to its vital functions in embryonic development and cellular differentiation. Research has shown that NOG is essential for proper skeletal patterning, and its dysregulation is linked to various skeletal disorders, including joint deformities and bone malformations. Additionally, NOG is involved in the maintenance of progenitor cell pools and has implications in regenerative medicine and tissue engineering. The recombinant production of NOG has become a focus of investigation to better understand its biological functions and potential therapeutic applications. By using recombinant DNA technology, researchers can generate large quantities of functional NOG protein, allowing for in-depth studies of its mechanisms of action in development and disease. Furthermore, investigations into NOG's interactions with other signaling pathways could pave the way for novel strategies in treating bone-related diseases and enhance the efficacy of stem cell therapies. Overall, the exploration of NOG and its recombinant forms represents a promising frontier in developmental biology and regenerative medicine, with significant implications for health and disease outcomes.
