Analytical Data
-
基因名
CAMK2N1
- Application
-
别名
CAMK2N1；Calcium/calmodulin-dependent Protein kinase II inhibitor 1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q7Z7J9
-
表达区间
1-78aa
-
氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMSEVLPY GDEKLSPYGD GGDVGQIFSC RLQDTNNFFG AGQNKRPPKL GQIGRSKRVV IEDDRIDDVL KNMTDKAPPG V
-
分子量
11 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CAMK2N1, or Calcium/Calmodulin-dependent Protein Kinase II Inhibitor 1, is a crucial regulatory protein that plays a significant role in neuronal signaling and calcium homeostasis. Research into CAMK2N1 has gained prominence due to its involvement in various physiological processes and its association with neurodegenerative diseases and psychiatric disorders. As a specific inhibitor of the calcium/calmodulin-dependent protein kinase II (CaMKII), CAMK2N1 modulates signaling pathways that are vital for synaptic plasticity, learning, and memory. Dysregulation of CAMK2N1 has been linked to conditions such as Alzheimer's disease, where impaired calcium signaling contributes to synaptic dysfunction and cognitive decline. Studies suggest that CAMK2N1 may serve as a potential therapeutic target, highlighting the importance of developing recombinant forms of this protein for further research. Recombinant CAMK2N1 can facilitate the investigation of its molecular functions, interactions with CaMKII, and its broader implications in neurobiology. Understanding CAMK2N1's role in synaptic mechanisms could unlock new avenues for treating neurological disorders, making it a focal point for both basic and translational research in neuroscience.
