Analytical Data
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基因名
XPO1
- Application
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别名
XPO1；CRM1；Exportin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14980
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表达区间
1-1071aa
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氨基酸序列
MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVL THLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCE GIKKYVVGLIIKTSSDPTCVEKEKVYIGKLNMVLVQILKQEWPKHWPTFI SDIVGASRTSESPCQNNMVILKLLSEEVFDFSSGQITQVKSKHLKDSMCN EFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGYIFETKLISTL IYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPL NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEA LHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHF DVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDS INLYKNMRETLVYLTHLDYVDTERIMTEKLHNQVNGTEWSWKNLNTLCWA IGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQ YPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFV QVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQ EHLIEKYMLLPNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACK AVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVTKQPLIRSMRT VKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREPEV LSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFL LLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTL LQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMF NLVEEGKISTSLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTG LFSLNQDIPAFKEHLRDFLVQIKEFAGEDTSDLFLEEREIALRQADEEKH KRQMSVPGIFNPHEIPEEMCD
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分子量
144 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XPO1 (Exportin 1), also known as CRM1 (Chromosomal Maintenance 1), is a pivotal nuclear export receptor that facilitates the transport of various proteins and RNA molecules from the nucleus to the cytoplasm. Its role is crucial for maintaining cellular homeostasis and regulating numerous biological processes, including cell cycle progression, apoptosis, and gene expression. Given its involvement in these fundamental processes, dysregulation of XPO1 is linked to various diseases, particularly cancer. Overexpression of XPO1 has been associated with the progression of several malignancies, making it a promising target for therapeutic interventions. Researchers have been increasingly focused on understanding the structure-function relationship of XPO1, leading to the development of small molecule inhibitors that can block its activity. The study of XPO1 recombinant proteins has facilitated detailed investigations into its functional mechanisms and interactions with substrate proteins. This research is instrumental in elucidating the nuances of XPO1-mediated transport and identifying potential biomarkers for disease prognosis and treatment response. Furthermore, as XPO1 and its inhibitors advance into clinical trials, the exploration of its biological implications continues to be a major focus in oncology and cellular biology, contributing to the broader understanding of nuclear-cytoplasmic transport processes.
