Analytical Data
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基因名
FLG2
- Application
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别名
FLG2;IFPS;Filaggrin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5D862
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FLG2 (Filaggrin 2) is a crucial protein involved in the keratinocyte differentiation process and plays a significant role in maintaining skin barrier function. It is a member of the filaggrin family, which contributes to the aggregation of keratin filaments, thereby providing structural integrity to the epidermis. With increasing evidence linking FLG2 dysfunction to various skin disorders such as atopic dermatitis, psoriasis, and ichthyosis, researchers have begun to explore its molecular mechanisms and therapeutic potential. The study of FLG2 recombinant proteins has gained traction as a means to better understand its biophysical properties and interactions within cellular environments. By producing FLG2 in a recombinant form, scientists can investigate its structural characteristics, functional roles, and possible implications for skin health. Additionally, such studies aim to elucidate the post-translational modifications that govern FLG2's stability and activity, as well as to explore its potential as a biomarker for disease states. The ongoing research into FLG2 recombinant proteins not only enhances our understanding of skin biology but also paves the way for novel therapeutic strategies targeting skin barrier dysfunctions, which are prevalent in many dermatological conditions. Thus, the investigation of FLG2 holds promise for advancing skin health and developing innovative treatments.












