Analytical Data
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Gene name
NGF
- Application
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Alternative Names
NGF；NGFB；Beta-nerve growth factor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01138
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Expression Region
122-241aa
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AA Sequence
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
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Molecular Weight
27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Nerve Growth Factor (NGF) is a crucial neurotrophic factor that plays a significant role in the growth, maintenance, and survival of neurons. It is vital for the development of the peripheral nervous system and has implications in various neurological conditions. The discovery of NGF in the 1950s opened new avenues for neurobiology, leading to a better understanding of neuronal health and disease. The recombinant form of NGF has become a focal point of research due to its potential therapeutic applications, particularly in treating neurodegenerative diseases such as Alzheimer's and conditions involving nerve damage or injury. Advances in genetic engineering techniques have enabled the production of recombinant NGF, allowing researchers to study its structure, function, and mechanisms in detail. Additionally, the ability to produce NGF in large quantities paves the way for clinical trials aimed at evaluating its efficacy in promoting neuronal survival and regeneration. Ongoing studies are investigating its role in pain modulation and its potential as a biomarker for various neurological disorders. Furthermore, the exploration of NGF's interactions with other growth factors and signaling pathways enhances our understanding of its multifaceted role in the nervous system. Overall, the research on recombinant NGF not only enriches our knowledge of neuronal biology but also holds promise for developing innovative therapies for disorders characterized by neuronal dysfunction.
