Analytical Data
-
Gene name
Tmc1
- Application
-
Alternative Names
(Beethoven protein)(Deafness protein)(Transmembrane cochlear-expressed protein 1)
-
Species
Mouse
-
Source
E. coli
-
Tag
N- His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8R4P5
-
Expression Region
1-757aa
-
Molecular Weight
90.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Tmc1, or Transmembrane Channel-like protein 1, is a crucial gene implicated in hearing function, as mutations in Tmc1 are associated with autosomal dominant and recessive forms of non-syndromic hearing loss. Research on Tmc1 recombinant protein is vital for understanding its role in the mechanosensitivity of hair cells in the inner ear, which are essential for converting sound waves into neural signals. The study of Tmc1 helps elucidate the molecular mechanisms underlying auditory transduction and identifies potential therapeutic targets for hearing loss. Recombinant Tmc1 protein has been produced in various systems to investigate its structural and functional properties. Understanding Tmc1's interactions with other proteins and its localization within the cell membrane can shed light on its role in the auditory system. Additionally, exploring the effects of specific mutations helps to understand the phenotypic diversity seen in hearing loss disorders. Overall, Tmc1 recombinant protein research is a crucial step toward developing strategies for preventing and treating auditory impairments, thus highlighting its significance in both basic and clinical research related to hearing health.
