Analytical Data
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Gene name
GLMN
- Application
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Alternative Names
GLMN；FAP48；FAP68；VMGLOM；Glomulin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92990
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Expression Region
2-594aa
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AA Sequence
AVEELQSII KRCQILEEQD FKEEDFGLFQ LAGQRCIEEG HTDQLLEIIQ NEKNKVIIKN MGWNLVGPVV RCLLCKDKED SKRKVYFLIF DLLVKLCNPK ELLLGLLELI EEPSGKQISQ SILLLLQPLQ TVIQKLHNKA YSIGLALSTL WNQLSLLPVP YSKEQIQMDD YGLCQCCKAL IEFTKPFVEE VIDNKENSLE NEKLKDELLK FCFKSLKCPL LTAQFFEQSE EGGNDPFRYF ASEIIGFLSA IGHPFPKMIF NHGRKKRTWN YLEFEEEENK QLADSMASLA YLVFVQGIHI DQLPMVLSPL YLLQFNMGHI EVFLQRTEES VISKGLELLE NSLLRIEDNS LLYQYLEIKS FLTVPQGLVK VMTLCPIETL RKKSLAMLQL YINKLDSQGK YTLFRCLLNT SNHSGVEAFI IQNIKNQIDM SLKRTRNNKW FTGPQLISLL DLVLFLPEGA ETDLLQNSDR IMASLNLLRY LVIKDNENDN QTGLWTELGN IENNFLKPLH IGLNMSKAHY EAEIKNSQEA QKSKDLCSIT VSGEEIPNMP PEMQLKVLHS ALFTFDLIES VLARVEELIE IKTKSTSEEN IGIK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GLMN, or Geranylgeranyltransferase type I (GGTase-I), is an essential enzyme involved in the post-translational modification of proteins through the addition of geranylgeranyl groups, which play a critical role in the membrane localization and functionality of numerous signaling proteins, particularly in the Rho family of GTPases. The research surrounding GLMN and its recombinant protein has gained significant attention due to its potential implications in various diseases, including cancer and cardiovascular disorders, where aberrant signaling pathways and lipid modifications are prevalent. Understanding the structure and function of GLMN is crucial not only for elucidating the molecular mechanisms underlying these diseases but also for identifying potential therapeutic targets. Recombinant GLMN protein allows for the establishment of in vitro and in vivo models to study the enzyme's activity, inhibition, and interaction with substrates and signaling pathways. Furthermore, the development of GLMN inhibitors could pave the way for novel treatment strategies that disrupt abnormal Rho signaling, further highlighting the importance of this enzyme in biomedical research. By advancing our knowledge of GLMN's role in cellular contexts, researchers aim to uncover new insights into its biochemical functions and therapeutic potential, establishing a foundational understanding for future clinical applications.
