Analytical Data
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Gene name
CHCHD7
- Application
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Alternative Names
CHCHD7；Coiled-coil-helix-coiled-coil-helix domain-containing Protein 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BUK0-2
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Expression Region
1-97aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMHQTRTG KKTVRMPSVT QRLRDPDINP CLSESDASTR CLDENNYDRE RCSTYFLRYK NCRRFWNSIV MQRRKNGVKP FMPTAAERDE ILRAVGNMPY
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Molecular Weight
14 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CHCHD7, belonging to the conserved helix-loop-helix (HLH) family of proteins, has garnered attention in recent years due to its crucial role in human development and disease. This protein is primarily implicated in the regulation of mitochondrial function and cellular metabolism, as well as in the development of the central nervous system and the heart. Mutations in the CHCHD7 gene have been linked to various congenital disorders, most notably Kallmann syndrome, characterized by hypogonadotropic hypogonadism and anosmia. The study of CHCHD7 recombinant proteins is critical for understanding its functional mechanisms at the molecular level, particularly how it interacts with other proteins and pathways involved in mitochondrial biogenesis and stress responses. By expressing and purifying CHCHD7 in recombinant systems, researchers aim to investigate its structural properties, post-translational modifications, and interactions, which can provide valuable insights into its role in normal physiology and disease. Moreover, understanding CHCHD7 function and its pathways might pave the way for potential therapeutic approaches for conditions associated with its dysfunction. As such, research on CHCHD7 recombinant proteins is not only fundamental for elucidating the basic biological processes in which this protein is involved but also holds promise for the development of interventions for related genetic disorders.
