Analytical Data
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Gene name
IFN-alpha 2/IFNA2
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简介
IFN-alpha 2/IFNA2 Protein, synthesized by macrophages, exhibits potent antiviral activities. Its interaction with IFNAR2 plays a pivotal role in signaling processes, contributing to the intricate network of antiviral defense mechanisms. IFN-alpha 2/IFNA2 Protein, Mouse is the recombinant mouse-derived IFN-alpha 2/IFNA2 protein, expressed by E. coli, with tag free.
- Application
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Biological Activity
Measured in a cell proliferation assay using TF-1 cells. The ED50 this effect is 0.0934-0.4718 ng/mL, corresponding to a specific activity is 2.12×106- 1.07×107 units/mg. Measured in a cell proliferation assay using TF-1 cells. The ED50 this effect is 0.4718 ng/mL, corresponding to a specific activity is 2.12×106units/mg.
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Alternative Names
Interferon alpha 2; IFNA2 Protein, Mouse
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Species
Mouse
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
P01573
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Expression Region
C24-E190
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Protein Length
Full Length of Mature Protein
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Molecular Weight
16-19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interferon-alpha 2 (IFN-alpha 2, or IFNA2) is a type of cytokine that plays a crucial role in the immune response against viral infections and malignancies. It is particularly known for its antiviral, antiproliferative, and immunomodulatory effects, making it an essential component in therapeutic strategies for various diseases, including hepatitis C and certain types of cancer. The recombinant form of IFN-alpha 2 has been extensively studied and developed for clinical use, providing targeted therapeutic benefits while minimizing systemic side effects. Research has shown that IFNA2 can enhance the activity of immune cells, such as natural killer (NK) cells and T lymphocytes, which are vital for the body’s defense mechanisms. Moreover, its potential synergistic effects when combined with other medications have opened avenues for innovative treatment regimens. Given the rising prevalence of viral infections and cancers worldwide, continued research into IFN-alpha 2, including the optimization of its recombinant production and understanding its molecular mechanisms, remains a high priority in biomedical research. As understanding of IFNA2's role in modulating immune responses deepens, it may lead to novel therapeutic applications and improved patient outcomes in the fight against infectious diseases and cancer.
