Analytical Data
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Gene name
Tmprss4
- Application
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Alternative Names
Channel-activating protease 2 ;mCAP2
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Species
Mouse
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8VCA5
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Expression Region
52-435aa
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Molecular Weight
57.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tmprss4, or transmembrane protease, serine 4, is a type II transmembrane serine protease that plays a crucial role in various physiological and pathological processes. Research has indicated that Tmprss4 is involved in cell signaling, modulation of extracellular matrix components, and regulation of cell adhesion and migration, which are fundamental for tissue homeostasis and repair. Its expression has been linked to several diseases, particularly cancers, where it may promote tumor cell invasion and metastasis by activating growth factors and degrading matrix proteins. The study of Tmprss4 as a recombinant protein allows for a clearer understanding of its enzymatic activity, structure-function relationships, and interaction with substrate proteins. This research is essential for elucidating the molecular mechanisms by which Tmprss4 contributes to disease progression and provides insights into potential therapeutic targets. By producing and characterizing recombinant Tmprss4, scientists are investigating its role in specific cellular contexts and exploring its potential as a biomarker or therapeutic target in cancer and other diseases. Understanding the dynamics of Tmprss4's function can lead to advancements in targeted therapy and improved clinical outcomes for patients.
