Analytical Data
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基因名
VPS13A
- Application
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别名
Chorea-acanthocytosis protein Chorein
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96RL7
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表达区间
3037-3140aa
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分子量
28.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS13A is a gene that encodes a protein involved in cellular processes such as membrane trafficking, lipid metabolism, and mitochondrial function. Mutations in VPS13A have been associated with Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder characterized by movement abnormalities, cognitive decline, and specific morphological changes in red blood cells. The understanding of VPS13A's function and its role in disease mechanisms is critical for developing therapeutic strategies. Research has highlighted the protein's involvement in the regulation of the endolysosomal system and its potential impacts on neuronal health. Recent studies have employed recombinant VPS13A proteins to elucidate its functional characteristics, structure, and interactions with other cellular components, thereby providing insights into how disruptions in its function can lead to neurodegeneration. Investigating VPS13A is vital for understanding the pathophysiology of ChAc and may hold promise for identifying novel targets for intervention, ultimately aiming to improve patient outcomes and quality of life for those affected by this debilitating condition.
