Analytical Data
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Gene name
PLP1
- Application
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Alternative Names
PLP1;PLP;Myelin proteolipid Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60201
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Expression Region
2-277aa
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AA Sequence
GLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYF SKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIF GDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDK FVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLC ADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATL VSLLTFMIAATYNFAVLKLMGRGTKF
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLP1 (Proteolipid Protein 1) is a crucial myelin-related protein predominantly expressed in oligodendrocytes, the myelinating cells of the central nervous system (CNS). Mutations or dysregulation of PLP1 are implicated in several demyelinating diseases, including Pelizaeus-Merzbacher disease, a severe neurodegenerative disorder characterized by hypomyelination. Given the importance of PLP1 in myelin formation and maintenance, its study has garnered considerable interest in the fields of neurobiology and regenerative medicine. Researchers utilize recombinant PLP1 proteins to investigate its structure-function relationships, post-translational modifications, and interactions with other myelin components. By using techniques such as protein expression in heterologous systems, purification, and functional assays, scientists aim to elucidate PLP1's role in myelination and its potential therapeutic implications for demyelinating conditions. Overall, understanding the intricacies of PLP1 biology not only enhances our comprehension of myelin pathophysiology but also guides the development of innovative strategies for repairing damaged CNS myelin.











