Analytical Data
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基因名
PNMA5
- Application
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别名
Tumor antigen BJ-HCC-25
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96PV4
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表达区间
4-442aa
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分子量
64.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PNMA5 (Parkin Interacting Protein 5) is a member of the PNMA (Parkinson’s Disease Protein 7) family, which has garnered attention due to its potential involvement in neurodegenerative diseases, particularly Parkinson's disease. Research indicates that PNMA5 may interact with the E3 ubiquitin ligase Parkin, which plays a critical role in mitochondrial quality control and proteostasis. Dysregulation of these pathways is implicated in the pathogenesis of Parkinson's disease, making PNMA5 a target for understanding the molecular mechanisms underlying neurodegeneration. Furthermore, studies suggest that PNMA5 may influence cell survival and apoptotic pathways, which are vital for neuronal health. Given its potential functions, the characterization of PNMA5 as a recombinant protein could provide insights into its structure-function relationships and interactions within cellular systems, paving the way for therapeutic strategies aimed at mitigating neurodegenerative diseases. By elucidating the role of PNMA5 in cellular processes, researchers aim to contribute to the broader understanding of the pathophysiology of Parkinson's disease and identify potential biomarkers for early diagnosis or novel drug targets. This underscores the importance of PNMA5 in neurobiology and its promise as a focal point for future research in the context of neurodegenerative conditions.
