Analytical Data
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Gene name
Trib3
- Application
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Alternative Names
(TRB-3)(Neuronal cell death-inducible putative kinase)
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Species
Mouse
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8K4K2
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Expression Region
1-354aa
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Molecular Weight
46.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Trib3, or Tribbles homolog 3, is an important protein involved in various cellular processes, including stress response, metabolism, and inflammation. This protein belongs to the Tribbles family, characterized by their role as pseudokinases, which means they have a kinase-like structure but lack traditional catalytic activity. Research indicates that Trib3 plays a significant role in regulating cellular homeostasis and response to insults, particularly in metabolic disorders such as obesity and diabetes. It has been implicated in the modulation of insulin signaling pathways and the regulation of adipocyte differentiation, highlighting its importance in energy metabolism. Additionally, Trib3 is associated with the cellular response to endoplasmic reticulum (ER) stress, acting as a protective factor against apoptosis in conditions of stress. Investigating Trib3 as a recombinant protein provides insights into its functional mechanisms and potential therapeutic applications, particularly in metabolic and inflammatory diseases. Understanding the structure-function relationship of Trib3 can pave the way for developing novel strategies to target its activity, offering new avenues for intervention in various pathologies linked to metabolic dysfunction and stress responses. Research efforts focus on producing recombinant Trib3 to study its biochemical properties, interactions with other cellular pathways, and its role in disease models, thus expanding our knowledge of its biological significance and potential as a therapeutic target.
