Analytical Data
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基因名
HIST1H2BN
- Application
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别名
Histone H2B.d ;H2B/d
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99877
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表达区间
2-126aa
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分子量
29.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H2BN is a gene that encodes a member of the histone H2B family, which plays a crucial role in the structural organization of chromatin and the regulation of gene expression. Histones are essential for packaging DNA into nucleosomes, thereby influencing accessibility to transcriptional machinery and ultimately impacting cellular processes such as proliferation, differentiation, and apoptosis. Recent studies have indicated that aberrations in histone gene expression can contribute to various diseases, including cancer. The HIST1H2BN gene, in particular, has garnered attention due to its potential involvement in oncogenic processes and its association with specific tumor types. Research into the recombinant protein of HIST1H2BN has focused on understanding its structural characteristics and how modifications, such as post-translational modifications, affect its function within the chromatin framework. By producing and studying this recombinant protein, researchers aim to elucidate its role in histone metabolism, its interactions with other chromatin-associated proteins, and its impact on gene regulation. Additionally, insights gained from HIST1H2BN studies could pave the way for novel therapeutic approaches targeting histone dysregulation in cancer and other diseases. Overall, the ongoing research on HIST1H2BN holds promise for expanding our comprehension of chromatin dynamics and its implications for cellular health and disease.
