Analytical Data
-
Gene name
CTSL
- Application
-
Alternative Names
CTSL;CTD small phosphatase-like Protein 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P07711
-
Expression Region
18-333aa
-
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSTLTFDHS LEAQWTKWKA MHNRLYGMNE EGWRRAVWEK NMKMIELHNQ EYREGKHSFT MAMNAFGDMT SEEFRQVMNG FQNRKPRKGK VFQEPLFYEA PRSVDWREKG YVTPVKNQGQ CGSCWAFSAT GALEGQMFRK TGRLISLSEQ NLVDCSGPQG NEGCNGGLMD YAFQYVQDNG GLDSEESYPY EATEESCKYN PKYSVANDTG FVDIPKQEKA LMKAVATVGP ISVAIDAGHE SFLFYKEGIY FEPDCSSEDM DHGVLVVGYG FESTESDNNK YWLVKNSWGE EWGMGGYVKM AKDRRNHCGI ASAASYPTV
-
Molecular Weight
38 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CTSL, or Cathepsin L, is a lysosomal cysteine protease that plays a crucial role in various physiological and pathological processes, including protein degradation, immune response, and tissue remodeling. Originally identified for its involvement in lysosomal degradation pathways, CTSL has garnered attention in recent years due to its dysregulation in several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Research indicates that altered CTSL activity can affect tumor progression and metastasis, making it a potential biomarker and therapeutic target in oncology. Additionally, its role in the processing of antigenic peptides suggests that CTSL may influence immune responses, further highlighting its significance in immunology. Scientists are increasingly interested in recombinant CTSL proteins to study their structure, function, and interactions in detail. The production of recombinant CTSL allows for the exploration of substrate specificity, enzyme kinetics, and the development of inhibitors that could serve as therapeutic agents. Overall, the study of recombinant CTSL is pivotal for understanding its biological role and therapeutic potential, especially in the context of disease mechanisms and interventions.
