Analytical Data
-
Gene name
TMPRSS6
- Application
-
Alternative Names
TMPRSS6；Transmembrane protease serine 6
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8IU80
-
Expression Region
1-461aa
-
AA Sequence
MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGY LRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFS QDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTC FFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPE GLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQ GPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGV LSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQG QWTIQNRRYHFLSSLWLPFLPPPPSLPSSTVTPSLEAQVPNLRGAARGAS RGWGWCQACCP
-
Molecular Weight
78 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMPRSS6, a transmembrane serine protease, plays a crucial role in iron homeostasis and is primarily involved in the regulation of hepcidin, a key biomarker for iron metabolism. Dysregulation of TMPRSS6 is associated with various disorders, including iron-refractory iron deficiency anemia (IRIDA) and iron overload conditions. Recent studies have highlighted its potential as a therapeutic target for managing iron-related diseases. The protein functions by modulating the signaling pathways that influence hepcidin levels, which in turn affect the absorption of dietary iron in the intestine and the release of iron from macrophages. Researchers have focused on characterizing the structure and function of TMPRSS6 through recombinant protein studies, which allow for the detailed investigation of its enzymatic activity and interactions with other proteins. Understanding TMPRSS6 at a molecular level is essential for elucidating the mechanisms underlying iron metabolism and developing potential strategies for treating related disorders. Advances in biotechnology have facilitated the production of recombinant TMPRSS6, providing a valuable tool for further exploration of its biological functions and therapeutic applications.
