Analytical Data
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基因名
AKAP12
- Application
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别名
AKAP12;AKAP250;A-kinase anchor Protein 12
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02952
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKAP12, also known as A-kinase anchoring protein 12, is a member of the AKAP family, which plays a crucial role in organizing signaling cascades by anchoring protein kinase A (PKA) and other signaling molecules to specific cellular sites. Research into AKAP12 has gained momentum due to its involvement in various cellular processes, including cell adhesion, migration, and proliferation. It has been implicated in several pathological conditions, notably cancer, where its expression levels and functional integrity often correlate with tumor progression and metastasis. The study of recombinant AKAP12 proteins presents a valuable opportunity to elucidate its functional mechanisms and interactions at a molecular level. By generating and characterizing these proteins, researchers can investigate the modulation of PKA signaling pathways and delineate how alterations in AKAP12 expression or function contribute to disease states. Additionally, the exploration of AKAP12's role in cellular compartments may reveal novel insights into intracellular signaling dynamics, potentially guiding therapeutic strategies targeting aberrant signaling in diseases. Thus, the recombinant AKAP12 protein serves as a critical tool for advancing our understanding of the intricate regulatory networks that govern cellular behavior and to explore its potential as a biomarker or therapeutic target in cancer and other diseases.












