Analytical Data
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Gene name
CHRDL1
- Application
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Alternative Names
CHRDL1；NRLN1；Chordin-like Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BU40
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Expression Region
92-237aa
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AA Sequence
PHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKELPGQSFDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRT
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Molecular Weight
74.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CHRDL1, or Chordin-like protein 1, is a member of the Chordin family of proteins, which play essential roles in developmental biology, particularly in the regulation of bone morphogenetic proteins (BMPs). BMPs are crucial signaling molecules that regulate various processes, including embryonic development, tissue homeostasis, and repair. Dysregulation of BMP signaling has been implicated in numerous diseases, including cancer and skeletal disorders. Recent studies have highlighted the importance of CHRDL1 in modulating BMP activity, suggesting it has potential therapeutic relevance. The protein acts as a BMP antagonist, inhibiting BMP signaling pathways and thus influencing cell fate decisions during development. As researchers seek to better understand the specific molecular mechanisms governing CHRDL1's interactions with BMPs, the production of recombinant CHRDL1 protein allows for detailed studies of its structural properties and functional dynamics. The generation of this protein through recombinant methods not only facilitates the exploration of its biological roles but also lays the groundwork for potential applications in regenerative medicine and disease treatment. Overall, the investigation of CHRDL1 and its recombinant forms is vital for advancing our understanding of BMP regulation and its broader implications in developmental biology and pathology.
