Analytical Data
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Gene name
GRWD1
- Application
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Alternative Names
CDW4; CUL4 and DDB1 associated WDR protein 4; Glutamate rich WD repeat containing 1; Glutamate rich WD repeat containing protein 1; Glutamate rich WD repeat protein GRWD; Glutamate-rich WD repeat-containing protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BQ67
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Expression Region
1-446aa
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AA Sequence
MAARKGRRRTCETGEPMEAESGDTSSEGPAQVYLPGRGPPLREGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKELHWHPQCPGLLVSTALSGFTIFRTISV
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Molecular Weight
75.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GRWD1, or GTPase-activating protein Rac1 downstream 1, is a crucial protein implicated in various cellular processes, including cell proliferation, differentiation, and stress responses. It belongs to the GRWD (glycine-rich RNA-binding) protein family, which is known for its roles in RNA metabolism and has been linked to tumorigenesis and cancer progression. Recent research has focused on the functional characterization of GRWD1 and its potential as a therapeutic target. Studies have shown that GRWD1 is involved in the regulation of ribosome biogenesis and plays a significant role in the cellular response to stress, making it a key player in maintaining cellular homeostasis. Furthermore, its overexpression has been correlated with several types of cancer, suggesting that GRWD1 might contribute to the malignancy of tumors. Efforts to produce recombinant GRWD1 protein have opened new avenues for understanding its structure-function relationship and interactions with other cellular components. By focusing on the biochemical properties and biological activities of GRWD1, researchers aim to elucidate its precise roles in normal physiology and disease contexts, which could lead to novel strategies for cancer treatment and other therapeutic interventions. This growing body of evidence underscores the importance of GRWD1 in cellular functions and its potential as a biomarker or target in cancer therapy, warranting further investigation.
