Analytical Data
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基因名
FBP1
- Application
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别名
FBP1；C1orf39；TOCA1;Formin-binding Protein 1-like
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09467
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表达区间
1-338aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBP1, or Fructose-1,6-bisphosphatase 1, is a key enzyme in gluconeogenesis, the metabolic pathway that results in the generation of glucose from non-carbohydrate substrates. Its regulation is critical in maintaining glucose homeostasis, particularly during fasting or intense exercise when glucose levels may drop. Dysregulation of FBP1 has been linked to metabolic disorders such as diabetes, making it a valuable target for therapeutic research. The recombinant production of FBP1 protein allows for detailed biochemical characterization and functional studies, enabling scientists to investigate its structure, enzymatic activity, and regulation mechanisms. Through techniques such as site-directed mutagenesis and structural analysis, researchers can derive insights into FBP1’s role in metabolic pathways and its interactions with other cellular components. Understanding the nuances of FBP1's function may reveal vital information about its potential as a drug target for managing metabolic diseases. Furthermore, recombinant FBP1 can be used in industrial applications, such as biofuel production, where enhancing glucose availability is vital. Overall, FBP1 recombinant protein research not only furthers our understanding of metabolic regulation but also opens new avenues for therapeutic and industrial advancements.
