Analytical Data
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基因名
IFNAR1
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简介
IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2]. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFNAR1 Protein, Cynomolgus (HEK293, His) is a recombinant Cynomolgus IFNAR1 (A25-K437) with C-terminal 6*His tag, which is produced in HEK293 cells.
- Application
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别名
Interferon Alpha/Beta Receptor 1; IFN-R-1; IFN-Alpha/Beta Receptor 1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; CRF2-1; Type I Interferon Receptor 1; IFNAR1; IFNAR
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种属
Cynomolgus
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_005548864
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表达区间
A25-K437
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氨基酸序列
AGGKNLKSPQKVEVDVIDDNFILRWNRSEESVGNVTFSFDYQKPEMDNWIKLPGCQNMTSTKCNFSSLKLNIYDEIKLRIRAEKENTSSWCEVDSFTPFRKAQIGPPEVHLEAEDKAIVIYISPPGTEDSVMWALDRSSFTYSLVIWKNSSSVEERIENIYSRHKISKLSPETTYCLKVKAALLTSRKIGVYGPVHCIKTTVENELPPPENIEVIVQNQNYVLKWDYTYANMTFQVQWLHAFLKRKPGNHLYKWKQIPDCENVTTTQCVFPPNTFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQASLLPPVFNIRSLSDSLHISIGAPKWSENKPVIQDYPLIYEILFWENTSKAERKIIKKKTDVTIPNLKPLTVYCVKARAHSMDEKLNKSSVFSDVVCEETKSGNTSK
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蛋白长度
Partial
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分子量
70-102 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFNAR1 (Interferon alpha/beta receptor subunit 1) is a crucial component of the type I interferon signaling pathway, which plays a pivotal role in the immune response to viral infections and other pathogens. The protein functions as a receptor for interferon-alpha and interferon-beta, mediating the activation of the JAK-STAT signaling cascade that results in the induction of numerous antiviral genes. Dysregulation of this pathway has been implicated in various diseases, including autoimmune disorders, cancer, and chronic viral infections. The recombinant production of IFNAR1 has garnered significant interest for a variety of applications, including the development of therapeutics that target the interferon signaling pathway, as well as for studying receptor biology and the broader immune signaling mechanisms. Understanding the structural and functional properties of IFNAR1 is vital for exploring its role in immune modulation and therapeutic interventions. Moreover, the recombinant protein can serve as a valuable tool for developing assays to screen for novel antiviral compounds and studying receptor-ligand interactions. Current research focuses on optimizing expression systems for high-yield production, characterizing the protein’s interactions with its ligands, and investigating its potential as a therapeutic target. The insights gained from IFNAR1 recombinant protein studies could lead to the advancement of innovative strategies to combat infectious diseases and enhance vaccine efficacy.
