Analytical Data
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基因名
GALT
- Application
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别名
GALT;Galactose-1-phosphate uridylyltransferase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07902
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表达区间
1-379aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMSRSGT DPQQRQQASE ADAAAATFRA NDHQHIRYNP LQDEWVLVSA HRMKRPWQGQ VEPQLLKTVP RHDPLNPLCP GAIRANGEVN PQYDSTFLFD NDFPALQPDA PSPGPSDHPL FQAKSARGVC KVMCFHPWSD VTLPLMSVPE IRAVVDAWAS VTEELGAQYP WVQIFENKGA MMGCSNPHPH CQVWASSFLP DIAQREERSQ QAYKSQHGEP LLMEYSRQEL LRKERLVLTS EHWLVLVPFW ATWPYQTLLL PRRHVRRLPE LTPAERDDLA SIMKKLLTKY DNLFETSFPY SMGWHGAPTG SEAGANWNHW QLHAHYYPPL LRSATVRKFM VGYEMLAQAQ RDLTPEQAAE RLRALPEVHY HLGQKDRETA TIA
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分子量
46 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GALT (galactose-1-phosphate uridylyltransferase) is a critical enzyme involved in the Leloir pathway of galactose metabolism, converting galactose-1-phosphate to UDP-galactose. Deficiency in GALT leads to classic galactosemia, a serious inherited disorder that can cause severe neurological damage, liver failure, and developmental delays if not managed with dietary restrictions. Research on GALT recombinant proteins is vital for understanding the enzyme's structure-function relationships, advancing diagnostic tools, and developing potential gene therapies. Recombinant GALT can be utilized in enzyme replacement therapies, providing a means to restore enzymatic activity in deficient individuals. Additionally, studying GALT in vitro offers insights into its interactions with galactose and other substrates, contributing to the broader understanding of carbohydrate metabolism and its implications for health. By elucidating the biochemical mechanisms underlying GALT's function and regulation, researchers aim to devise novel therapeutic approaches to mitigate the impact of galactosemia and explore the potential of GALT in metabolic engineering applications.
