Analytical Data
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基因名
PIK3C2a
- Application
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别名
PIK3C2a；Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00443
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIK3C2a (Phosphoinositide 3-kinase C2 alpha) is a member of the class II phosphoinositide 3-kinase family, which plays a crucial role in various cellular processes, including membrane trafficking, cell growth, and survival. Research on PIK3C2a has garnered significant attention due to its involvement in several diseases, including cancer and metabolic disorders. Unlike class I PI3Ks, which are well-characterized for their role in signaling pathways related to growth factors, class II PI3Ks and particularly PIK3C2a have distinct functions that remain less understood. Recent studies have suggested that PIK3C2a regulates endosomal dynamics and autophagy through its lipid kinase activity, impacting cellular homeostasis. The recombinant expression of PIK3C2a protein enables researchers to investigate its biochemical properties, interactions with other proteins, and specific roles in lipid metabolism. Additionally, understanding the structure-function relationship of PIK3C2a can unveil potential therapeutic targets for diseases where its dysregulation occurs. This makes PIK3C2a an important focus in molecular biology and pharmacology, fostering further exploration into its mechanism of action and implications in health and disease.
