Analytical Data
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Gene name
HKE2
- Application
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Alternative Names
H2 KE2; H2KE2; HKE2; HLA class II region expressed gene KE2; KE 2; KE2; KE2 protein; KE2. mouse. homolog of; PFD6_HUMAN; Pfdn6; Prefoldin subunit 6; Protein Ke2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15212
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Expression Region
1-129aa
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AA Sequence
MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLLGPVLVKQELGEARATVGKRLDYITAEIKRYESQLRDLERQSEQQRETLAQLQQEFQRAQAAKAGAPGKA
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Molecular Weight
39.93 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HKE2, a recombinant protein derived from the human sodium/potassium ATPase alpha-2 subunit, has gained attention in biomedical research due to its significant role in various physiological and pathological processes. It is known to participate in ion transport across cell membranes, which is crucial for maintaining cellular homeostasis and electrical excitability in tissues such as muscle and nerve. The therapeutic potential of HKE2 is particularly noteworthy in cardiovascular diseases, as it is involved in the modulation of cardiac contractility and heart rhythm. Additionally, HKE2 has been implicated in cancer biology, where its expression levels may correlate with tumor progression and patient prognosis. Recent studies have focused on elucidating the detailed mechanisms of HKE2's action and its interactions with other cellular components. By employing advanced techniques such as recombinant DNA technology, researchers are able to produce HKE2 in various expression systems, facilitating the exploration of its structural and functional properties. Understanding HKE2’s multifaceted roles could lead to novel therapeutic strategies targeting ion transport dysregulation in diseases, highlighting the importance of this protein in both fundamental biology and clinical applications.
