Analytical Data
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Gene name
IFN-gamma R2
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Mouse IFN-gamma R1(HY-P72611) is immobilized at 2 μg/mL (100 μL/well), it binds to Recombinant Mouse IFN-gamma R2 in the presence of Recombinant Mouse IFN-gamma(HY-P7071). The ED 50 for this effect is 0.8900 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Mouse IFN-gamma R1 (HY-P72611) is immobilized at 2 μg/mL (100 μL/well), it binds to Recombinant Mouse IFN-gamma R2 in the presence of Recombinant Mouse IFN-gamma (HY-P7071). The ED 50 for this effect is 0.8900 μg/mL.
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Alternative Names
Interferon gamma receptor 2; IFN-γ Receptor II; IFNGR2; IFNGT1
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
Q63953
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Expression Region
A20-V243
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Protein Length
Partial
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Molecular Weight
40-45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFN-gamma R2, a receptor for interferon-gamma (IFN-γ), plays a crucial role in mediating immune responses, particularly in the context of viral infections and autoimmune diseases. As a key component of the Type II interferon signaling pathway, IFN-gamma R2 is involved in the activation of various immune cells, including macrophages and T cells, leading to enhanced expression of major histocompatibility complex (MHC) molecules and pro-inflammatory cytokines. Research has shown that dysregulation of IFN-gamma signaling can contribute to the pathogenesis of conditions such as chronic inflammatory diseases and cancer. Consequently, the study of recombinant IFN-gamma R2 protein has gained attention for its potential therapeutic applications. By producing this protein in a laboratory setting, researchers aim to explore its functional characteristics, improve understanding of its signaling mechanisms, and investigate its role in modulating immune responses. Moreover, recombinant IFN-gamma R2 could be utilized to develop targeted therapies for diseases where IFN-γ signaling is compromised or to enhance the effectiveness of existing treatments. Overall, understanding the biological properties and mechanisms of action of IFN-gamma R2 is essential for harnessing its potential in clinical applications, making it a focal point of immunological research.
