Analytical Data
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Gene name
PALB
- Application
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Alternative Names
PALB；FANCN；Partner and localizer of BRCA2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P02766
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Expression Region
21-147aa
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AA Sequence
GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
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Molecular Weight
43.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The PALB (Partner and Localizer of BRCA2) protein serves as a crucial mediator in the DNA damage repair process, particularly linking BRCA1 and BRCA2, two vital proteins implicated in the maintenance of genomic stability. Research has shown that mutations in the PALB gene are associated with an increased risk of breast and pancreatic cancers, underscoring its importance in cancer biology. PALB functions in multiple aspects of homologous recombination repair by facilitating the recruitment of BRCA2 to sites of DNA damage, thereby ensuring proper repair of double-strand breaks. The understanding of PALB’s structural and functional dynamics has been significantly advanced through studies of its protein interactions and its role in the repair pathway. Such insights are not only pivotal for elucidating the mechanisms underlying genomic integrity but also hold potential for the development of targeted therapies in cancers associated with PALB mutations. As a result, ongoing research is focused on characterizing PALB’s interactions with other repair proteins and its regulation, which could inform novel strategies for cancer prevention and treatment, particularly in BRCA-related malignancies.
