Analytical Data
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基因名
HOXA13
- Application
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别名
Homeo box 1J; Homeo box A13; Homeobox 1J; Homeobox A13; Homeobox protein Hox A13; Homeobox protein Hox-1J; Homeobox protein Hox-A13; Homeobox protein HOXA13; Homeobox1J; HomeoboxA13; HOX 1; HOX 1J; Hox 1J protein; HOX A13; HOX1; HOX1J; HOXA 13; HOXA13; HXA13_HUMAN; Transcription factor HOXA13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31271
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表达区间
1-388aa
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氨基酸序列
MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA AGAGGGGFPH PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPG AASAYSSAPG EAPPSAAAAA AAAAAAAAAA AAASSSGGPG PAGPAGAEAA KQCSPCSAAA QSSSGPAALP YGYFGSGYYP CARMGPHPNA IKSCAQPASA AAAAAFADKY MDTAGPAAEE FSSRAKEFAF YHQGYAAGPY HHHQPMPGYL DMPVVPGLGG PGESRHEPLG LPMESYQPWA LPNGWNGQMY CPKEQAQPPH LWKSTLPDVV SHPSDASSYR RGRKKRVPYT KVQLKELERE YATNKFITKD KRRRISATTN LSERQVTIWF QNRRVKEKKV INKLKTTS
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分子量
39.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXA13 is a member of the Homeobox (HOX) gene family, which plays a critical role in embryonic development and patterning of limbs and reproductive organs. Research on HOXA13 has garnered significant attention due to its involvement in congenital disorders, such as hand-foot-genital syndrome (HFGS), characterized by malformations of the limbs and genitalia. The gene's unique expression patterns during early developmental stages underscore its importance in specifying anterior-posterior axis development. Furthermore, HOXA13 protein undergoes specific post-translational modifications, which influence its transcriptional regulatory functions. As a transcription factor, HOXA13 binds to DNA and regulates the expression of target genes crucial for organogenesis. Understanding the structure and function of HOXA13 recombinant protein is vital for elucidating its biological roles and the molecular mechanisms underlying associated developmental anomalies. Additionally, generating HOXA13 recombinant proteins allows for in-depth biochemical studies, providing insights into its interactions with other protein partners and regulatory pathways. This research holds promise for advancing gene therapy approaches and developing targeted treatments for HOXA13-related congenital disorders.
