Analytical Data
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Gene name
HOXD13
- Application
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Alternative Names
HOXD13; HOX4I; Homeobox protein Hox-D13; Homeobox protein Hox-4I
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35453
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Expression Region
1-343aa
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AA Sequence
MSRAGSWDMDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPPSAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS
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Molecular Weight
64.68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HOXD13 is a member of the homeobox gene family, which plays a crucial role in the regulation of embryonic development, particularly in limb formation and morphogenesis. Mutations or dysregulation of HOXD13 are associated with several congenital malformations, including synpolydactyly and other limb patterning disorders. Given its significance in developmental biology, recombinant HOXD13 protein has garnered attention as a valuable tool for understanding the molecular mechanisms underlying limb development and associated pathologies. The ability to produce HOXD13 in a recombinant form allows researchers to investigate its functional properties, protein interactions, and downstream signaling pathways in a controlled environment. By analyzing the recombinant protein, scientists can explore how specific mutations affect its activity and elucidate the gene's role in transcriptional regulation during development. Furthermore, this research has potential implications for therapeutic strategies aimed at correcting developmental anomalies caused by HOXD13-related disorders. By deepening our understanding of HOXD13 through recombinant protein studies, we can contribute to the broader field of developmental biology and regenerative medicine.
