Cat: PA1000-1372

Recombinant Human GULP1 Protein,His

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Analytical Data

  • Gene name

    GULP1

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    GULP1;CED6;GULP;PTB domain-containing engulfment adapter Protein 1

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9UBP9

  • Expression Region

    1-304aa

  • AA Sequence

    MGSSHHHHHH SSGLVPRGSH MGSMNRAFSR KKDKTWMHTP EALSKHFIPY NAKFLGSTEV EQPKGTEVVR DAVRKLKFAR HIKKSEGQKI PKVELQISIY GVKILEPKTK EVQHNCQLHR ISFCADDKTD KRIFTFICKD SESNKHLCYV FDSEKCAEEI TLTIGQAFDL AYRKFLESGG KDVETRKQIA GLQKRIQDLE TENMELKNKV QDLENQLRIT QVSAPPAGSM TPKSPSTDIF DMIPFSPISH QSSMPTRNGT QPPPVPSRST EIKRDLFGAE PFDPFNCGAA DFPPDIQSKL DEMQEGFKMG LTLEGTVFCL DPLDSRC

  • Molecular Weight

    37 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

GULP1, a member of the GULP family of proteins, has garnered significant interest due to its roles in cellular processes such as endocytosis, apoptosis, and the regulation of signaling pathways. It primarily functions as an adaptor protein that links ubiquitinated membrane proteins to the clathrin-mediated endocytic machinery, thereby facilitating the internalization and degradation of these proteins. Recent studies have shown that GULP1 is implicated in various physiological and pathological conditions, including cancer progression and neurodegenerative diseases. Its ability to interact with multiple proteins and influence cellular signaling pathways highlights its potential as a therapeutic target. Due to the complexity and specificity of its interactions, the study of recombinant GULP1 proteins has become essential for understanding their functional roles in cellular contexts. Researchers are increasingly focusing on characterizing the structure-function relationships of GULP1 and exploring its potential applications in targeted therapies, making it a crucial area of investigation in contemporary biomedical research. Understanding the precise mechanisms by which GULP1 operates will provide deeper insights into its contributions to cellular homeostasis and disease pathology.

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