Analytical Data
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基因名
GSN
- Application
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别名
GSN；Gelsolin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06396
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表达区间
514-782aa
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氨基酸序列
DEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA
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分子量
33.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of GSN (Gelsolin) recombinant proteins is rooted in the understanding of their crucial role in cellular processes, particularly in actin cytoskeleton dynamics. Gelsolin is an actin-binding protein that regulates the assembly and disassembly of actin filaments, which is vital for various cellular functions such as motility, shape maintenance, and intracellular transport. Abnormalities in gelsolin function have been linked to several diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. Consequently, the recombinant expression of GSN provides a valuable tool for investigating its structure-function relationships and interactions with actin and other cellular components. By producing GSN in a controlled laboratory setting, researchers can perform in-depth studies, enabling the elucidation of its regulatory mechanisms and potential therapeutic applications. This research not only enhances our fundamental understanding of cell biology but also opens avenues for developing interventions targeting gelsolin-related pathologies.
