Analytical Data
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Gene name
IMP-2
- Application
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Alternative Names
IMP 2; IMP A2; IMP.18P; IMP2; IMPA 2; Impa2; IMPA2_HUMAN; IMPase 2; Inosine monophosphatase 2; Inositol 1; Inositol 1(or 4) monophosphatase 2; Inositol monophosphatase 2; Inositol monophosphatase 2 variant 1; Inositol monophosphatase 2 variant 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14732
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Expression Region
1-288aa
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AA Sequence
MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK
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Molecular Weight
31.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IMP-2 (insulin-like growth factor 2 mRNA-binding protein 2) is a member of the IGF-II mRNA-binding protein family, which plays a significant role in post-transcriptional regulation of gene expression. Research has indicated that IMP-2 is involved in various cellular processes, including cellular differentiation, proliferation, and response to stress, thereby influencing development and cancer progression. It is known to bind to specific RNA targets, stabilizing them and enhancing their translation, which affects the expression levels of proteins critical in various biological pathways. Elevated levels of IMP-2 have been observed in several types of tumors, suggesting its potential as a biomarker for cancer diagnosis and prognosis. Furthermore, its role in neural development and function highlights its importance in neurobiology. Given the multifaceted functions of IMP-2, ongoing studies focus on elucidating its molecular mechanisms and interactions within the cellular environment. Understanding the reconstitution and functional dynamics of IMP-2 could lead to novel therapeutic strategies targeting cancer and neurodegenerative diseases. Thus, the research on IMP-2 recombinant proteins aims to better characterize this multifunctional protein, explore its regulatory networks, and assess its potential as a therapeutic target.
