Analytical Data
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基因名
ING3
- Application
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别名
ING3; HSPC301; Inhibitor of growth protein 3; p47ING3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NXR8
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表达区间
1-418aa
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氨基酸序列
MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE RRSLELDTPS QPVNNHHAHS HTPVEKRKYN PTSHHTTTDH IPEKKFKSEA LLSTLTSDAS KENTLGCRNN NSTASSNNAY NVNSSQPLGS YNIGSLSSGT GAGAITMAAA QAVQATAQMK EGRRTSSLKA SYEAFKNNDF QLGKEFSMAR ETVGYSSSSA LMTTLTQNAS SSAADSRSGR KSKNNNKSSS QQSSSSSSSS SLSSCSSSST VVQEISQQTT VVPESDSNSQ VDWTYDPNEP RYCICNQVSY GEMVGCDNQD CPIEWFHYGC VGLTEAPKGK WYCPQCTAAM KRRGSRHK
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分子量
46.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ING3 (Inhibitor of Growth 3) is a member of the ING family of proteins, which are implicated in various cellular processes, including cell growth regulation, apoptosis, and DNA damage response. The research surrounding ING3 has gained momentum due to its potential role as a tumor suppressor and its involvement in maintaining genomic stability. Recent studies have highlighted that ING3 interacts with key regulatory pathways, including those controlled by p53 and histone modifications, suggesting its critical function in cell cycle control and transcriptional regulation. Moreover, alterations in ING3 expression have been observed in several cancers, indicating its potential as a biomarker for tumorigenesis and a target for therapeutic interventions. The investigation of ING3 not only enhances our understanding of cancer biology but also opens avenues for developing novel strategies in cancer treatment, promoting the need for further exploration into its structural and functional properties, mechanisms of action, and implications in cancer therapies. Understanding the molecular mechanisms by which ING3 exerts its effects on cellular processes is essential for uncovering its full potential in cancer research and therapy.
