Analytical Data
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基因名
INPP5K
- Application
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别名
43 kDa form skeletal muscle and kidney enriched inositol phosphatase; Inositol polyphosphate 5-phosphatase K; INP5K_HUMAN; INPP5K; muscle and kidney-enriched inositol phosphatase; PPS
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BT40
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表达区间
1-448aa
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氨基酸序列
MSSRKLSGPKGRRLSIHVVTWNVASAAPPLDLSDLLQLNNRNLNPDIYVIGLQELNSGIISLLSDAAFNDSWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIEDFGLRFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYIDISNIPTTEDEFLLCYYSNSLRSVVGISRPFQIPPGSLREDPLGEAQPQI
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分子量
74.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INPP5K, or inositol polyphosphate-5-phosphatase K, is a member of the inositol phosphate phosphatase family, which plays a crucial role in the regulation of cellular signaling pathways by modulating inositol phosphate levels. Research has shown that INPP5K is involved in various biological processes, including insulin signaling, cell growth, and differentiation, which highlights its potential implications in metabolic disorders and cancer. The enzyme catalyzes the dephosphorylation of inositol polyphosphates, thereby influencing the phosphoinositide signaling cascade. Recombinant INPP5K proteins have become valuable tools for elucidating the molecular mechanisms of inositol metabolism and assessing the functional consequences of altered INPP5K activity in pathological conditions. Understanding the structure and function of INPP5K is essential for developing targeted therapeutic strategies for diseases associated with dysfunctional inositol signaling, such as diabetes and certain types of cancer. Recent studies focusing on the purification and characterization of INPP5K have paved the way for deeper insights into its enzymatic properties and regulatory mechanisms, fostering the exploration of INPP5K as a potential biomarker or therapeutic target. Thus, the investigation of recombinant INPP5K not only enhances our understanding of inositol phosphate metabolism but also opens new avenues for clinical applications, making it a significant focus in molecular and cellular biology research.
