Analytical Data
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基因名
CRYl1
- Application
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别名
CRYl1；CRY；Lambda-crystallin homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y2S2
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表达区间
2-319aa
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氨基酸序列
ASSAAGCVV IVGSGVIGRS WAMLFASGGF QVKLYDIEQQ QIRNALENIR KEMKLLEQAG SLKGSLSVEE QLSLISGCPN IQEAVEGAMH IQECVPEDLE LKKKIFAQLD SIIDDRVILS SSTSCLMPSK LFAGLVHVKQ CIVAHPVNPP YYIPLVELVP HPETAPTTVD RTHALMKKIG QCPMRVQKEV AGFVLNRLQY AIISEAWRLV EEGIVSPSDL DLVMSEGLGM RYAFIGPLET MHLNAEGMLS YCDRYSEGIK HVLQTFGPIP EFSRATAEKV NQDMCMKVPD DPEHLAARRQ WRDECLMRLA KLKSQVQPQ
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分子量
35.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRY1 (Cryptochrome 1) is a key regulator of circadian rhythms in mammals, playing a crucial role in the maintenance of the body's internal clock and responses to light. As a member of the cryptochrome family of photoreceptors, CRY1 influences various physiological processes, including sleep regulation, metabolism, and hormonal balance, by modulating the expression of clock genes. Understanding the structure and function of CRY1 is essential for unraveling its mechanistic role in circadian biology. The study of recombinant CRY1 protein has gained prominence in recent years due to its potential applications in chronotherapy and the treatment of circadian-related disorders, such as sleep disorders, depression, and metabolic syndrome. Additionally, producing CRY1 as a recombinant protein allows researchers to explore its interactions with other proteins and its role in signaling pathways at a molecular level. Structural studies of recombinant CRY1 have provided insights into its photolyase-like domain, essential for its photoreceptive function, and how it undergoes conformational changes upon light exposure. Overall, research on recombinant CRY1 protein not only enhances our understanding of circadian mechanisms but also opens new avenues for therapeutic interventions targeting circadian disruptions.
