Cat: PA1000-1591

Recombinant Human IL-2 Protein,His

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Analytical Data

  • 基因名

    IL-2

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    IL2RA;Interleukin-2 receptor subunit alpha

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P60568

  • 表达区间

    21-153aa

  • 氨基酸序列

    APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT

  • 分子量

    41.5 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

Interleukin-2 (IL-2) is a key cytokine that plays a crucial role in the immune response, particularly in the proliferation and activation of T cells. It was first discovered in the late 1970s and has since been recognized for its therapeutic potential in various diseases, including cancer and autoimmune disorders. Due to its significant role in immune regulation, research on recombinant IL-2 has gained momentum, especially in the context of immunotherapy. Recombinant DNA technology has enabled the production of high-purity IL-2 for both research and clinical applications. This has opened avenues for investigating its use as an adjuvant in cancer vaccination, enhancing the efficacy of anti-tumor responses by promoting T cell expansion and activity. Moreover, IL-2 has been utilized in combination therapies to synergize with other immune-modulating agents. However, its clinical use is limited by adverse effects such as vascular leak syndrome and dose-dependent toxicity. As a result, ongoing research aims to develop safer IL-2 variants, optimize dosing regimens, and explore novel delivery methods to maximize its therapeutic benefits while minimizing side effects. Investigations into the mechanisms of action of IL-2 at the cellular and molecular levels are also being conducted to better understand its role in immune responses. Overall, the study of recombinant IL-2 continues to be a significant area of interest, contributing to advancements in immunotherapy and the development of novel treatment strategies for cancer and other immune-related conditions.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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