Analytical Data
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基因名
IL34
- Application
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别名
IL34;C16orf77;Interleukin-34
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZMJ4
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表达区间
21-242aa
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氨基酸序列
NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LP
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL34 (Interleukin-34) is a cytokine that plays a crucial role in the regulation of immune responses and the maintenance of various immune cell types, particularly monocytes and macrophages. Discovered in 2008, IL34 binds to the colony-stimulating factor 1 receptor (CSF1R), which is essential for the survival, proliferation, and differentiation of these myeloid cells. Research indicates that IL34 is involved in several physiological and pathological processes, including tissue repair, inflammation, and various autoimmune diseases. Importantly, it has emerged as a potential therapeutic target due to its role in modulating immune system activity. The production of recombinant IL34 proteins has become vital for studying its biological functions and interactions in vitro and in vivo. These studies can provide insights into the mechanisms by which IL34 affects immune responses and contribute to the development of novel therapeutic strategies for diseases characterized by dysregulated immune activity. The ongoing investigation into IL34’s roles, mechanisms, and therapeutic potentials underscores the significance of this cytokine in immunology and its promise in clinical applications.
