Analytical Data
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Gene name
OMA1
- Application
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Alternative Names
OMA1；MPRP1；Metalloendopeptidase OMA1. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96E52
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Expression Region
14-524aa
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AA Sequence
HVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSF LPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEV TAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAI IVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTH LEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAV KEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLN SVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICP RDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRAS SVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMC NCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIP LTYIVEKRTGS
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Molecular Weight
75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OMA1 is a mitochondria-localized metalloprotease that plays a crucial role in maintaining mitochondrial function and dynamics. Its significance has gained attention due to its involvement in the quality control of mitochondria, particularly under stress conditions. Research indicates that OMA1 participates in the proteolytic regulation of mitochondrial fusion and fission processes, which are essential for mitochondrial morphology and function. The enzyme is also implicated in the activation of the mitochondrial stress response, particularly during instances of oxidative stress or perturbations to mitochondrial homeostasis. Dysregulation of OMA1 has been linked to various pathophysiological conditions, including neurodegenerative diseases, highlighting its potential as a therapeutic target. Moreover, recent studies have suggested that OMA1 functions in the processing of specific mitochondrial proteins, influencing mitophagy and apoptosis pathways. Thus, understanding the molecular mechanisms underlying OMA1 activity and regulation can provide insights into mitochondrial biology and disease states, making it a significant focus in the field of cell biology and biomedicine. Ongoing research aims to elucidate the intricate roles of OMA1 in mitochondrial dynamics, its interactions with other mitochondrial proteins, and its potential as a biomarker or target for therapeutic interventions in mitochondrial-related disorders.
