Analytical Data
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基因名
ACKR2
- Application
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别名
ACKR2；CCBP2；CCR10；CMKBR9；Atypical chemokine receptor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00590
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表达区间
1-384aa
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氨基酸序列
MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA
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分子量
46.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACKR2, or atypical chemokine receptor 2, is a member of the chemokine receptor family that plays a pivotal role in regulating immune responses and inflammation. Its primary function involves the binding and internalization of chemokines, which are molecules that guide the migration of immune cells. ACKR2 mediates the scavenging of specific inflammatory chemokines, thereby modulating their availability and activity in the tissue microenvironment. This unique property positions ACKR2 as a crucial player in the resolution of inflammation and the prevention of chronic inflammatory diseases. Recent studies have highlighted the potential of ACKR2 in therapeutic applications, particularly in contexts such as cancer, autoimmune disorders, and infectious diseases, where excessive inflammation is detrimental. The recombinant expression of ACKR2 has become a focus of research to better understand its structural characteristics, functional dynamics, and interaction with various chemokines. Investigating ACKR2 as a recombinant protein enables researchers to explore its biochemical properties in vitro, assess its role in cell signaling pathways, and evaluate its potential as a target for drug development. Overall, the study of ACKR2 and its recombinant forms presents significant opportunities for advancing our understanding of immune regulation and for developing innovative therapeutic strategies to combat diseases characterized by dysregulated chemokine activity.
