Analytical Data
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Gene name
KIAA1737
- Application
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Alternative Names
CIPC; KIAA1737CLOCK-interacting pacemaker; CLOCK-interacting circadian protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9C0C6
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Expression Region
1-399aa
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AA Sequence
MERKNPSRESPRRLSAKVGKGTEMKKVARQFGMAAAESDKDSGFSDGSSECLSSAEQMESEDMLSALGWSREDRPRQNSKTAKNAFPTLSPMVVMKNVLVKQGSSSSQLQSWTVQPSFEVISAQPQLLFLHPPVPSPVSPCHTGEKKSDSRNYLPILNSYTKIAPHPGKRGLSLGPEEKGTSGVQKKICTERLGPSLSSSEPTKAGAVPSSPSTPAPPSAKLAEDSALQGVPSLVAGGSPQTLQPVSSSHVAKAPSLTFASPASPVCASDSTLHGLESNSPLSPLSANYSSPLWAAEHLCRSPDIFSEQRQSKHRRFQNTLVVLHKSGLLEITLKTKELIRQNQATQVELDQLKEQTQLFIEATKSRAPQAWAKLQASLTPGSSNTGSDLEAFSDHPAI
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Molecular Weight
69.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIAA1737, also known as TBRG4, is a gene of considerable interest in the field of molecular biology due to its potential involvement in various cellular processes, including cell signaling, cell proliferation, and differentiation. Research has indicated that KIAA1737 might play a pivotal role in the development of certain diseases, including cancer, making it a target for therapeutic intervention. The gene is located on chromosome 17, and its protein product is characterized by several functional domains that suggest a role in protein-protein interactions. Recent studies have focused on the recombinant expression of KIAA1737 to better understand its structure-function relationship and biological activity. By producing the KIAA1737 recombinant protein, researchers aim to elucidate its role in tumorigenesis and its potential as a biomarker for various malignancies. Moreover, understanding its signaling pathways may open up novel avenues for targeted therapies. Overexpression or mutation of KIAA1737 has been linked to altered cellular responses, highlighting its significance in maintaining cellular homeostasis. Therefore, the exploration of KIAA1737 recombinant protein serves not only to unravel the molecular mechanisms underlying disease progression but also to provide insights into potential clinical applications in diagnosis and treatment strategies. As research continues, the KIAA1737 protein may emerge as a crucial component in the development of innovative therapeutic modalities, emphasizing the importance of this gene in both fundamental biology and clinical research.
