Analytical Data
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Gene name
UGT1A7
- Application
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Alternative Names
UGT1A7；GNT1；UGT1；UDP-glucuronosyltransferase 1A7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HAW7
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Expression Region
26-530aa
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AA Sequence
GKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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Molecular Weight
60.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The UGT1A7 gene encodes a member of the UDP-glucuronosyltransferase (UGT) family of enzymes, which are crucial for the detoxification and elimination of various endogenous and exogenous compounds through the process of glucuronidation. This metabolic pathway plays a vital role in drug metabolism, pharmacokinetics, and the clearance of potentially harmful substances from the body. Research on UGT1A7 is particularly significant due to its involvement in the metabolism of several therapeutic agents and carcinogens, making it important for cancer research and drug development. Variants in the UGT1A7 gene can lead to differences in enzyme activity, impacting individual responses to drugs and susceptibility to toxic effects. The recombinant expression of UGT1A7 proteins in suitable systems allows for the detailed study of their biochemical properties, substrate specificity, and interactions with drugs. Understanding these characteristics is essential for predicting drug efficacy and safety, as well as for developing personalized medicine approaches. As a result, the investigation of UGT1A7 and its substrate interactions has garnered considerable interest across various fields, including pharmacology, toxicology, and cancer therapy, making it a pivotal enzyme in understanding individual metabolic responses and therapeutic interventions.
