Analytical Data
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Gene name
PSMD7
- Application
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Alternative Names
PSMD7；MOV34L；26S proteasome non-ATPase regulatory subunit 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51665
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Expression Region
1-324aa
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AA Sequence
MPELAVQKVV VHPLVLLSVV DHFNRIGKVG NQKRVVGVLL GSWQKKVLDV SNSFAVPFDE DDKDDSVWFL DHDYLENMYG MFKKVNARER IVGWYHTGPK LHKNDIAINE LMKRYCPNSV LVIIDVKPKD LGLPTEAYIS VEEVHDDGTP TSKTFEHVTS EIGAEEAEEV GVEHLLRDIK DTTVGTLSQR ITNQVHGLKG LNSKLLDIRS YLEKVATGKL PINHQIIYQL QDVFNLLPDV SLQEFVKAFY LKTNDQMVVV YLASLIRSVV ALHNLINNKI ANRDAEKKEG QEKEESKKDR KEDKEKDKDK EKSDVKKEEK KEKK
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMD7, a crucial component of the 26S proteasome, plays a significant role in regulating protein degradation and maintaining cellular protein homeostasis. The proteasome is essential for degrading misfolded, damaged, or unneeded proteins, thereby influencing various cellular processes, including cell cycle regulation, apoptosis, and immune responses. Recent studies have indicated that PSMD7 not only participates in proteasomal degradation but also has implications in the modulation of various signaling pathways, which can lead to the development of certain diseases, including cancer. Given its pivotal role in the ubiquitin-proteasome system (UPS), PSMD7 has garnered attention as a potential therapeutic target for the treatment of malignancies, where proteasome function is often dysregulated. Research on PSMD7 recombinant protein involves examining its structure, function, and interactions with other proteasome subunits and regulatory proteins. By producing PSMD7 in a recombinant form, scientists aim to elucidate its mechanistic roles in proteasome activity and explore its potential as a biomarker or target for drug development. This research may provide valuable insights into the molecular underpinnings of various disorders and facilitate the design of innovative therapeutic strategies that leverage the proteasome’s degradation pathways. Overall, the investigation of PSMD7 recombinant protein holds significant promise for enhancing our understanding of proteostasis and its implications in health and disease.
