Analytical Data
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Gene name
TPOR
- Application
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Alternative Names
TPOR;TPOR;Thrombopoietin receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40238
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Expression Region
22-353aa
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AA Sequence
QVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPR EKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRT QRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRY GPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDG PKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGS WSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRAR CCPRDRYPIWENCEEEEKTNPGLQTPQFSRCH
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TPOR (Thrombopoietin receptor) is a crucial component in the regulation of megakaryocyte differentiation and platelet production. As a primary receptor for thrombopoietin, it plays a significant role in hematopoiesis and maintaining platelet homeostasis. Dysregulation of TPOR has been implicated in various hematological disorders, including thrombocytopenia and essential thrombocythemia. Recent studies have aimed to characterize TPOR at the molecular level, focusing on its structure and function to understand the mechanisms that govern its activity. The development of TPOR recombinant proteins has provided valuable tools for both basic research and therapeutic applications, allowing scientists to explore its signaling pathways and interactions with other cellular components. Furthermore, engineered TPOR variants are being investigated for their potential in treating disorders related to platelet production. By enhancing our understanding of TPOR and its role in platelet biology, researchers hope to pave the way for innovative treatments for blood-related diseases, making it a pivotal area of study in molecular and cellular biology. The insights gained from TPOR research hold promise for advancing therapeutic strategies targeting platelet disorders and improving patient outcomes.











