Analytical Data
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Gene name
KUB3
- Application
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Alternative Names
ATP23; KUB3; XRCC6BP1Mitochondrial inner membrane protease ATP23 homolog; EC 3.4.24.-; Ku70-binding protein 3; XRCC6-binding protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6H3
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Expression Region
1-246aa
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AA Sequence
MAGAPDERRR GPAAGEQLQQ QHVSCQVFPE RLAQGNPQQG FFSSFFTSNQ KCQLRLLKTL ETNPYVKLLL DAMKHSGCAV NKDRHFSCED CNGNVSGGFD ASTSQIVLCQ NNIHNQAHMN RVVTHELIHA FDHCRAHVDW FTNIRHLACS EVRAANLSGD CSLVNEIFRL HFGLKQHHQT CVRDRATLSI LAVRNISKEV AKKAVDEVFE SCFNDHEPFG RIPHNKTYAR YAHRDFENRD RYYSNI
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Molecular Weight
28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KUB3, a member of the KUB family of proteins, has garnered significant interest in recent years due to its potential roles in various biological processes, including cell proliferation, differentiation, and apoptosis. This protein is particularly intriguing because of its involvement in the regulation of key signaling pathways that govern these critical cellular functions. Initial studies have indicated that KUB3 may interact with specific cellular substrates, thus influencing their activity and stability. Researchers are keen to understand the molecular mechanisms by which KUB3 exerts its effects, particularly in relation to cancer biology, where dysregulation of similar proteins has been implicated in tumorigenesis. Furthermore, the investigation of KUB3's expression patterns in different tissues and under various physiological conditions may provide insights into its functional relevance and potential as a biomarker or therapeutic target. As such, ongoing research is focused on elucidating the structure-function relationship of KUB3, its interactions with other proteins, and the downstream consequences of these interactions on cellular behavior. This multifaceted approach aims to uncover the broader roles of KUB3 in health and disease, and to pave the way for novel therapeutic strategies that could mitigate the impacts of diseases characterized by the dysregulation of cellular signaling pathways.
