Analytical Data
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基因名
LDLRAD3
- Application
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别名
LDLRAD3; LRAD3; Low-density lipoprotein receptor class A domain-containing protein 3; LDLR class A domain-containing protein 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86YD5
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表达区间
1-345aa
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氨基酸序列
MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALVLHHQRKRNNLMTLPVHRLQHPVLLSRLVVLDHPHHCNVTYNVNNGIQYVASQAEQNASEVGSPPSYSEALLDQRPAWYDLPPPPYSSDTESLNQADLPPYRSRSGSANSASSQAASSLLSVEDTSHSPGQPGPQEGTAEPRDSEPSQGTEEV
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分子量
63.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LDLRAD3 (Low-Density Lipoprotein Receptor Adaptor Protein 3) is a protein involved in lipid metabolism and cellular cholesterol regulation. It is part of a larger family of proteins that modulate the function of low-density lipoprotein receptors, which play a crucial role in the uptake of cholesterol and lipoproteins by cells. Dysregulation of cholesterol homeostasis is closely linked to various metabolic disorders, including cardiovascular diseases and obesity. Research into the structure and function of LDLRAD3 has gained importance due to its potential role in influencing lipid levels and its implications in health. Recent studies aimed at understanding how LDLRAD3 interacts with other cellular components highlight its significance in the endosomal recycling of LDL receptors and its impact on cholesterol absorption and metabolism. By exploring the mechanisms that govern LDLRAD3 activity, researchers hope to identify new therapeutic targets for managing cholesterol-related diseases. The development of recombinant LDLRAD3 protein is critical for advancing these studies, as it allows for detailed biochemical and biophysical analyses. Such work can provide insights into the protein's functional domains and interaction partners, paving the way for novel interventions in dyslipidemia and related disorders. As the understanding of LDLRAD3 continues to evolve, it holds promise for contributing to strategies aimed at improving cardiovascular health and developing innovative treatments for metabolic diseases.
