Analytical Data
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Gene name
NAP1L1
- Application
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Alternative Names
NAP1L1;NRP;Nucleosome assembly Protein 1-like 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55209
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Expression Region
1-388aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MADIDNKEQS ELDQDLDDVE EVEEEETGEE TKLKARQLTV QMMQNPQILA ALQERLDGLV ETPTGYIESL PRVVKRRVNA LKNLQVKCAQ IEAKFYEEVH DLERKYAVLY QPLFDKRFEI INAIYEPTEE ECEWKPDEED EISEELKEKA KIEDEKKDEE KEDPKGIPEF WLTVFKNVDL LSDMVQEHDE PILKHLKDIK VKFSDAGQPM SFVLEFHFEP NEYFTNEVLT KTYRMRSEPD DSDPFSFDGP EIMGCTGCQI DWKKGKNVTL KTIKKKQKHK GRGTVRTVTK TVSNDSFFNF FAPPEVPESG DLDDDAEAIL AADFEIGHFL RERIIPRSVL YFTGEAIEDD DDDYDEEGEE ADEEGEEEGD EENDPDYDPK KDQNPAEC
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NAP1L1 (Nucleosome Assembly Protein 1 Like 1) is a crucial protein involved in chromatin dynamics and nucleosome assembly, playing a significant role in gene regulation and DNA repair. Research has indicated that NAP1L1 is not only essential for the proper formation of nucleosomes but also influences various cellular processes, including transcriptional regulation, chromatin remodeling, and cellular responses to stress. Recent studies have revealed its involvement in cancer development, suggesting that dysregulation of NAP1L1 may be linked to tumorigenesis. Given its importance, recombinant NAP1L1 protein is increasingly being utilized for biochemical assays to better understand its structure-function relationships and interactions with other chromatin-associated proteins. The production and characterization of recombinant NAP1L1 provide insights into its role in facilitating nucleosome assembly and unraveling its potential as a therapeutic target in diseases characterized by chromatin misregulation. Understanding NAP1L1’s mechanistic pathways and its influence on chromatin dynamics can pave the way for novel strategies in treating cancers and other diseases associated with chromatin dysfunction.
