Analytical Data
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基因名
ITGAM
- Application
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别名
ITGAM；CD11B；CR3A；Integrin alpha-M
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种属
Human
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表达系统
E. coli
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标签
6xHis-GST tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11215
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表达区间
46-150aa
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氨基酸序列
VLFQGPLGSPEFRTVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDGRTRAPPPPPLRSGCQSPKGSVGCCHRAITSITPWGLTGLEGFFAERRNYIRIGEWDAPCSGALSAAGVVVTRSVTATLASALAPAPFAFFPSFLATFAGFPRQALNRGLPLGFRFSALRHL
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分子量
57.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITGAM, or integrin alpha M, also known as CD11b, is a cell surface receptor primarily expressed on myeloid cells, playing a crucial role in immune response by mediating adhesion, phagocytosis, and the activation of leukocytes. The study of ITGAM recombinant proteins has garnered attention due to its involvement in various pathological conditions, including autoimmune diseases, cancer, and infectious diseases. Research indicates that polymorphisms in the ITGAM gene are linked to increased susceptibility to diseases such as systemic lupus erythematosus (SLE), highlighting its potential as a therapeutic target. The recombinant version of this protein is pivotal for studying its functional properties, understanding its role in cell signaling and adhesion processes, and exploring its implications in disease mechanisms. By producing ITGAM as a recombinant protein, scientists can develop antibodies for diagnostic purposes, investigate the receptor's interactions with ligands, and test potential inhibitory compounds. This research is critical for elucidating the molecular pathways involving ITGAM, paving the way for innovative treatment strategies and improving our understanding of immune-related disorders.
