Analytical Data
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基因名
EphA5
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简介
The EPHA5 protein is a receptor tyrosine kinase that promiscuously binds to the GPI-anchored ephrin-A ligand to initiate bidirectional signaling. It is involved in forward and reverse signaling pathways, and EFNA5 may serve as its cognate ligand. EPHA5 Protein, Human (HEK293, His) is the recombinant human-derived EPHA5 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
EHK-1; EK7; BSK; EHK1; HEK7; TYRO4; EphA5; Rek7; TYRO4HEK7CEK7
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种属
Human
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P54756-1
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表达区间
A26-P573
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蛋白长度
Extracellular Domain
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分子量
68-80 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphA5 is a member of the Eph receptor tyrosine kinase family, which plays critical roles in various biological processes, including cell adhesion, migration, and neuronal development. The Eph receptors interact with their ligands, known as Ephrin-A and Ephrin-B, to mediate bidirectional signaling that is pivotal for tissue remodeling and the establishment of cellular boundaries. Research on EphA5 has gained significant interest due to its involvement in cancer progression and metastasis, where altered expression or activity can influence tumor growth and the metastatic potential of cancer cells. Additionally, EphA5 has been implicated in neurological disorders, making it a potential therapeutic target. The generation of recombinant EphA5 proteins has enabled researchers to elucidate its signaling mechanisms, study its role in various pathophysiological contexts, and explore its potential as a biomarker or target for drug development. As such, the study of EphA5 recombinant proteins is essential for advancing our understanding of its functional characteristics and developing strategies for intervention in diseases associated with aberrant EphA5 activity.
