Analytical Data
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Gene name
NTAL
- Application
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Alternative Names
LAT2;LAB;NTAL;WBS15;Linker for activation of T-cells family member 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9GZY6
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Expression Region
27-243aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MRCSRPGAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE EDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NTAL (Non-T cell activation linker) is a crucial adaptor protein primarily studied for its role in cellular signaling processes, particularly in immune responses. It belongs to the family of signaling proteins that modulate the activity of various receptors and kinases, influencing T cell activation, proliferation, and differentiation. Research on NTAL has gained prominence due to its involvement in regulating allergic and autoimmune diseases, where improper signaling can lead to hyperactive immune responses. Additionally, NTAL's dysregulation has been associated with certain hematological malignancies, making it a potential biomarker for disease prognosis and a target for therapeutic interventions. The development of recombinant NTAL involves producing the protein in various expression systems, enabling detailed biochemical and biophysical characterization. These studies provide valuable insights into NTAL's structure-function relationship and its interactions with other signaling molecules, paving the way for targeted therapies that could modulate immune responses in a controlled manner. Understanding NTAL's mechanistic pathways holds promise for advancing our knowledge of immune regulation and addressing diseases linked to immune dysfunction. As such, NTAL serves as a vital subject in immunological research, with its recombinant forms being instrumental in elucidating its biological functions and therapeutic potential.
